Why Some People Have Weird Drug Reactions – VICE

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Why do some people feel wide awake on weed, tired on MDMA, and chill on stimulants?
Who the hell gets miserable on MDMA? Or calm on speed, or aggressive on pot? Every group of friends has the rogue drug user with a strange reaction to a particular substance. What’s unclear is why one person’s reaction to a drug can be so altogether different from another person’s. Is it genetic makeup, an interaction with other drugs, the wiring of the brain, or something else entirely? .en.

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