Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test

Introduction Historically, Cannabis sativa has been used by many cultures for medical purposes. The plant contains more than 80 cannabinoids, of which two have been the most studied: tetrahydrocannabinol (THC), responsible for the main psychoactive effects of cannabis, and cannabidiol (CBD), which may account for up to 40% of the plant. 1 , 2 CBD has been shown to be a safe compound with a favorable adverse effects profile.