Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test

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Introduction Historically, Cannabis sativa has been used by many cultures for medical purposes. The plant contains more than 80 cannabinoids, of which two have been the most studied: tetrahydrocannabinol (THC), responsible for the main psychoactive effects of cannabis, and cannabidiol (CBD), which may account for up to 40% of the plant. 1 , 2 CBD has been shown to be a safe compound with a favorable adverse effects profile.

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